Journal article
Maturation-related changes in the pattern of renal sympathetic nerve activity from fetal life to adulthood
LC Booth, L Bennet, SJ Guild, CJ Barrett, CN May, AJ Gunn, SC Malpas
Experimental Physiology | Published : 2011
Abstract
Sympathetic nerve activity (SNA) has two main properties, the presence of co-ordinated bursts of activity, indicative of many nerve fibres firing at a similar time, and entrainment of the bursts to the cardiac cycle, due to inhibitory input from baroreceptors to a network of cell groups within the CNS. Although this patterning is used as a 'gold standard' for the identification of successful nerve recordings, the maturation of these basic features of SNA from fetal life to adulthood has not been investigated. Using a telemetry-based nerve amplifier, renal SNA (RSNA) was recorded in preterm (99 ± 1 days gestation; term 147 days) and near-term fetal sheep (119 ± 0 days gestation), without anae..
View full abstractRelated Projects (1)
Grants
Awarded by National Health and Medical Research Council, Australia
Funding Acknowledgements
This study was supported by grants from the Health Research Council of New Zealand, the March of Dimes Birth Defects Foundation, the Auckland Medical Research Foundation and the Lottery Grants Board of New Zealand. L. C. B. was supported by a University of Auckland Doctoral Scholarship. C.N.M. was supported by a Research Fellowship from the National Health and Medical Research Council, Australia (no. 566819).